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-synuclein, that is a major component of Lewy bodies, in PARK one in 1997 and parkin in PARK 2 in 1998, which happens to be an E3 ubiquitin ligase and brings about endoplasmic reticulum (ER) stress, counsel that dysfunction with the intracellular proteinase systems, such as ubiquitin-proteasome technique or lysosomal technique, which removes unnece